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Poisonous Concoction Pathfinder Build

Poisonous Concoction Pathfinder Build

Powerful DoT build based on the newly added Thrown/Projectile Attack that deals extra damage with Poison

 Poisonous Concoction
Pathfinder build

Updated for Patch 3.19

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Guide notes
November 01, 2021
-Build created
October  17, 2022
-Updated for Patch 3.19
Build overview



Boss DPS:



Poisonous Concoction is a new type of Unarmed/Thrown Attack that was initially introduced in Patch 3.15. The previous ones weren't really that popular and were considered to be badly underperforming, but the Poisonous Concoction looks completely different. It's a skill that adds base Chaos Damage by consuming charges from Life Flask and deals increased Poison Damage. The skill itself requires you to wear no main-hand weapon, but in return, rewards you with massive DPS, that can be easily scaled by increases to the maximum number of Projectiles, and bonuses to Poison/Chaos/DoT damage. 

When looking at the skill's base attributes, you notice Flask Charges and Poison damage - which are both what Pathfinder excels in, making it the truly best character class for this build. On top of increasing your Flask Charge recovery, Poison DPS, you get a lot of defensive utility from various sources, that make it a very tanky and durable build which includes:

  1. Approximately 70% Spell Suppression chance that reduces your incoming Spell Damage significantly
  2. Very high Evasion Rating which should allow you to avoid around 70% of incoming Attacks
  3. 100% Flask uptime with incredibly quick recovery on Life Flask
  4. Additional Ward from Vorana's Preparation that also debilitates enemies, reducing their damage by 10% and causing them to move 20% slower
  5. Easily capped Chaos Resistance
  6. Ghost Dance quickly generates a moderate amount of Energy Shield to mitigate some of the incoming damage

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1. Gameplay

This feels like a typical Ranged build that instead of firing projectiles from your Bow, makes you throw acidic flasks that apply potent Poison/DoT effects on impact. Unlike projectiles, Flasks don't deal any damage (or hit enemies) while mid-air, so you won't benefit from Pierce/Chain or Fork. This playstyle resembles grenadiers, which is completely new to Path of Exile. On the other hand, you benefit from amazing mobility, good clear speed, and solid single-target DPS that Ranger characters usually offer. With Pathfinder's Ascendancy, and multiple defensive mechanics this build has to offer, you can easily jump into the middle of monster packs, face-tank end-game Bosses, and smoothly progress through content, making it a very well-balanced and enjoyable character build.

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2. Build's PROS & CONS

  • very tanky thanks to powerful synergies between Items and Passives
  • high sustainable DPS with strong AoE
  • all content viable
  • unique playstyle
  • can do most Map mods
  • requires a number of specific Rare Items and Uniques to maintain high defensive capabilities
  • you will need to keep a track of Plague Bearer's incubation


3. Leveling tips

Leveling up with Poison/Ranger is easy, however, it's not advised to do so using Poisonous Concoction. You will be unable to sustain enough Life Flask charges to benefit from the extra damage added, and you will not have enough extra Projectiles, making this build feel very weak initially. It's recommended to use a Claw and Cobra Lash, which offers decent DPS and extra chain, allowing you to level up your character quicker. Personally, I have respected at around level 60 after completing the third Lab and having allocated Replenishing Remedies and Nature's Boon Passives. You can start using Concoction in act 4 after gaining Greater Projectile Support Gem. Below you can find some basic leveling Skill Gem setups and several very useful Uniques for this build. 

Suggested leveling Gem setups:

Cobra Lash setup
Cobra Lash Cobra Lash - an amazing leveling Chaos/Poison Skill that offers extra Chain, increasing your clear speed by a lot
Lesser Multiple Projectiles Lesser Multiple Projectiles Support - increases the number of your Cobra Lash's projectiles
Lesser Poison Support Lesser Poison Support - adds extra Chaos Damage to Attacks and increases your chance to Poison on Hit
Void Manipulation Support Void Manipulation Support - increases Chaos Damage dealt with by supported skills
Vicious Projectiles Support Vicious Projectiles Support - increases Caustic Arrow's Damage over Time
Utility Gems
Herald of Agony Herald of Agony - Herald Skill which increases your Chance to Poison and Poison Damage
Malevolence Malevolence - the best Aura for this build which greatly increases your Damage over Time
Flame Dash Flame Dash - a great mobility Spell that allows you to progress faster or avoid incoming damage
Withering Step Withering Step - grants you the Elusive buff and applies Withered to enemies, increasing Chaos Damage they take
Despair Despair - the best Curse for this build. Later on, it's applied by Witchfire Brew, but during the campaign, you may want to cast the Curse manually against Bosses for extra damage


We recommend killing all the Bandits for two additional Passive Points

Leveling Skill Trees:

34 Points Skill Tree
Priorities: 1) Heart of Oak 2) Poisonous Fangs 3) Toxic Strikes 4) Swift Venoms 5) Acuity

65 Points Skill Tree
Priorities: 1) Fatal Toxins 2) Clever Thief 3) Revenge of the Hunted 4) Entropy 5) Ballistics

Recommended leveling items:

Le Heup of AllLe Heup of All - one of the best leveling Rings for this build. At least one of these is recommended so that you don't have to worry about Attributes and Resistances
Adds 1 to 4 Physical Damage to Attacks
+(10-30) to all Attributes
(10-30)% increased Damage
(10-30)% increased Rarity of Items found
+(10-30)% to all Elemental Resistances
Mortem MorsuMortem Morsu - a very powerful Unique Claw that is available early on in the campaign. It has a high base DPS and an increased chance to inflict poison. The Life Gain on Hit will simply make you instantly replenish your Life as well
+20 Life gained for each Enemy hit by Attacks
(75-100)% increased Physical Damage
20% increased Attack Speed
25% increased Critical Strike Chance
+40% to Global Critical Strike Multiplier
(10-20)% of Physical Damage Converted to Chaos Damage
25% reduced Enemy Stun Threshold with this Weapon
60% chance to Poison on Hit
SnakebiteSnakebite - There are some ways in which you can get Frenzy Charges (Poacher's Mark, Blood Rage, Mark Mastery). If you're able to do so, equip these Gloves for much more Damage.
(150-180)% increased Evasion Rating
+(60-70) to maximum Life
2% increased Attack Speed per Frenzy Charge
6% increased Accuracy Rating per Frenzy Charge
10% reduced Frenzy Charge Duration per Frenzy Charge
Attacks have 60% chance to Poison while at maximum Frenzy Charges
+5% to Damage over Time Multiplier for Poison per Frenzy Charge

GoldrimGoldrim - the best leveling Helmet in Path of Exile that grants a lot of Elemental Resistances and you can easily use it on lower Tier Maps as well

+(30-50) to Evasion Rating
10% increased Rarity of Items found
+(30-40)% to all Elemental Resistances
Reflects 4 Physical Damage to Melee Attackers
Level Requirement reduced by 100 (Hidden)

Karui WardKarui Ward - great leveling Amulet for any character that deals damage with Projectiles - it fits for both Cobra Lash and Poisonous Concoction

+(20-30) to Dexterity
+(20-30) to Strength
+100 to Accuracy Rating
30% increased Projectile Speed
10% increased Movement Speed
30% increased Projectile Damage


4. Final Skill Tree, Ascendancy Points, and Pantheon

Final Skill Tree:

113 Points Final Skill Tree (Doesn't include Passives from Cluster Jewel(s))
120 Points Path of Building (PoB) link

Ascendancy points:

Preferably in that order:

  1. Nature's Reprisal
  2. Nature's Boon
  3. Master Toxicist
  4. Nature's Adrenaline


Major God: Soul of Solaris: 6% additional Physical Damage Reduction while there is only one nearby Enemy; 20% chance to take 50% less Area Damage from Hits

Minor God: Soul of Ryslatha: Life Flasks gain 3 Charges every 3 seconds if you haven't used a Life Flask Recently


5. Final Gems links

[DPS] Poisonous Concoction
Poisonous Concoction Poisonous Concoction - the primary Attack in this build. In this setup, it will throw an incredible amount of Projectiles and will have its' damage further amplified by Life Flasks with nearly endless Charges
Unbound Ailments Unbound Ailments Support - greatly increases your damage with ailments which are the main source of your damage
Greater Multiple Projectiles Support Greater Multiple Projectiles Support - increases the number of Poisonous Concoction projectiles, which is one of the best ways to scale this skill's DPS
Greater Volley Support Greater Volley Support - once again you get to increase the number of your maximum projectiles, but also they appear to be thrown in a more concentrated manner, allowing you to apply more poison stacks on a single enemy
Void Manipulation Support Void Manipulation Support - increases Chaos Damage significantly, but makes the linked skill unable to deal Elemental Damage
Vicious Projectiles Support Vicious Projectiles Support - boots Chaos Damage over Time from linked Projectile Skills (along with other less relevant bonuses)
[UTILITY] Utility Gems
Ancestral Protector Ancestral Protector - summons a Totem that will boost your Attack Speed when active
Steelskin Steelskin - the best Guard Spell for this build which creates a protective shield that absorbs some of the incoming damage
Withering Step Withering Step - grants you the Elusive buff for a duration and applies Withered stacks to enemies in the radius
Enhance Support Enhance Support - boosts the Quality and effect of all linked Gems in this setup
[UTILITY] Flame Dash
Flame Dash Flame Dash - the recommended Movement Skill for this build. It lets you progress faster through areas and avoid incoming damage
Second Wind Support Second Wind Support - adds extra charges to your Flame Dash Skill
(Socketed in Shield with increased Reservation Efficiency)
Malevolence Malevolence - the best DPS Aura for DoT builds which greatly increases your damage output and opens up various options on Watcher's Eye Jewel
Grace Grace - increases your Evasion Rating significantly, which is one of your core defensive mechanics
Herald of Agony Herald of Agony - increases your Chance to Poison enemies, and the damage you deal with it
[UTILITY] Plague Bearer
Arctic Armour Plague Bearer - allows you to store some of the Poison Damage dealt to gain stacks when Incubating. You can unleash the stored damage and deal it around your character, quickly killing regular enemies in the radius. The Divergent version can also increase your DPS while infecting
Increased Area of Effect Increased Area of Effect - optional support Gem which boosts the radius of Plague Bearer
[UTILITY] Wither Spell Totems
Wither Wither - a Spell that applies Withered debuff to enemies, which increases the Chaos Damage they take from other sources
Spell Totem Support Spell Totem Support - allows you to summon Totems that will cast WIther at the enemies for you
Multiple Totems Support Multiple Totems Support - lets you spawn additional Totems so that you can apply WIthered faster, but also use Ancestral Protector at the same time
Increased Duration Support Increased Duration Support - increases the Duration of your Totems and the WIthered debuff they apply

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5. Gear Setup

Below you will find the recommended equipment for our Poisonous Concoction Pathfinder Build. While this build is very flexible and doesn't require any specific Uniques to work, you will be able to benefit fully from all its features only with several inexpensive Items listed below. Overall, this is a medium-budget build that could be played as a League Starter as well, however, we have not tested it in such a form so we would rather not evaluate its' capabilities in this guide. If you yourself try that out, please let us know in the comments how it worked for you!

Using this opportunity, we would like to invite you to check our POE Currency market where you can buy cheap Orbs including Exalted Orbs, Chaos Orbs, and more, from other players using real money. 


Stat priorities on items:

  1. Maximum Life
  2. Elemental Resistances
  3. Gem Level of Poisonous Concoction
  4. Chaos Damage over Time Multiplier with Poison
  5. Evasion Rating
  6. Spell Suppression Chance
  7. Attack Speed
  8. Poison Damage/Duration
  9. Chaos Resistance
  10. Block Chance
Rare Helmet(Helmet) Rare Helmet - the best possible option for this build. You can get high defensive stats here and reduce the Chaos Resistance of enemies. It's important to pick one with Evasion if you allocated Spell Suppression Mastery as we recommended earlier
Min. requirements:
80 Maximum Life
90% Total Elemental Resistances
400 Accuracy Rating
Evasion Rating
Optional affixes:
Nearby enemies have -#% to Chaos Resistance
increased Stun and Block Recovery
The Devouring Diadem(Helmet) The Devouring Diadem - You would use this Helmet if you struggle with Mana Regeneration and Mana Reservation Efficiency, two very common issues with this build. It's not good for anything else.
+1 to Level of Socketed Gems
Socketed Gems have 25% increased Reservation Efficiency
Trigger Level 15 Feast of Flesh every 5 seconds
(180-220)% increased Energy Shield
10% chance for Energy Shield Recharge to start when you use a Skill
Eldritch Battery
Veiled Suffix
Helmet enchantment:
Plague Bearer Buff grants +20% to Poison Damage over Time Multiplier while Infecting
Poisonous Concoction enchantments
Carcass Jack(Body Armour) Carcass Jack - a very solid and inexpensive Armour for this build. It grants extra Life, Resistances, and a lot of bonuses to AoE Damage that you are going to deal
(120-150)% increased Evasion and Energy Shield
+(50-70) to maximum Life
+(9-12)% to all Elemental Resistances
(40-50)% increased Area of Effect
(40-50)% increased Area Damage
Extra gore
The Covenant(Body Armour) The Covenant - One of the best Armours for more DPS, the 7th Support Gem for more Chaos Damage is extremely good, but your Skills now cost Life too requiring Life Leech to counter this effect.
Socketed Gems are Supported by Level 29 Added Chaos Damage
Skills gain a Base Life Cost equal to 100% of Base Mana Cost
+(20-30) to Intelligence
(210-250)% increased Energy Shield
10% increased maximum Life
Assassin's Garb(Body Armour) Rare Armour - when it comes to raw defensive capabilities, a Rare piece with high bonus Life and possibly extra ES based on Maximum Life will be the best-in-slot
Min. requirements:
100 Maximum Life
10% increased Maximum Life
70% Total Resistances
Optional affixes:
You can apply an additional Curse
Spell Suppression Chance
Evasion Rating
Rare Shield(Shield) Rare Shield - you need high defensive stats and a 30% increased Mana Reservation Efficiency on your Shield. It's best to pick one with Evasion, but that's not mandatory
Min. requirements:
100 Maximum Life
Socketed Gems have 30% increased Reservation Efficiency
50% Total Resistances
Optional affixes:
Chance to Suppress Spell Damage
Accuracy Rating
Boots(Boots) Rare Boots - basically for extra Movement Speed and defensive stats. You could also look for Onslaught if you can afford such a pair
Min. requirements:
30% Movement Speed
60 Maximum Life
60% Total Elemental Resistances
Evasion Rating
Optional affixes:
chance to gain Onslaught for 4 seconds on Kill
Spell Suppression
Atziri's Step(Boots) Atziri's Step - a solid and inexpensive pair that grants extra Spell Suppression chance with Life and Movement speed bonuses
180% increased Evasion Rating
+(55-75) to maximum Life
30% increased Movement Speed
+(20–26)% chance to Suppress Spell Damage
Boot enchantment:
16% increased Attack and Cast Speed if you've Killed Recently
80% chance to Avoid being Stunned if you've Killed Recently
Stygian Vise(Belt) Rare Belt - preferably a Stygian Vise for an extra Abyssal Socket and high defensive stats
Min. requirements:
90 Maximum Life
70% Total Elemental Resistances
40 Strength
Optional affixes:
increased Maximum Life
Increased Damage/Chaos Damage
#% Chance for Flasks you use to not consume Charges
Rare Amulet(Amulet) Rare Amulet - you are looking for a Life/Chaos DoT Multi Amulet. There are plenty of other stats you can find here, so just look for stuff that you are missing 
Min. requirements:
50 Maximum Life
16% Chaos Damage over Time Multiplier
40 Intelligence
Optional affixes:
+1 to Level of all Skill / Chaos Skill Gems
Accuracy Rating
Elemental Resistances
Chaos Damage
Recommended Anointments:
Sovereignty (Mana management, Auras)
Heart of Darkness/Corruption (DPS)
Two Stone Ring(Ring) Rare Rings - aim to fix all your Resistances and Attributes needs here, as well as provide extra Life. Bonus Attack Speed, Accuracy Rating, or Despair Curse on Hit can be useful as well
Min. requirements:
60 maximum Life
90% Total Elemental Resistances
Optional affixes:
Non-Channelling Skills have -# to Total Mana Cost
Curse Enemies with Despair on Hit, with #% increased Effect
Accuracy Rating
Circle of Nostalgia(Ring) Circle of Nostalgia - grants additional bonuses when you are affected by the Herald of Agony. Look for an increased Chaos Damage bonus and Herald's buff effect on this Ring
<One to three random Synthesis implicit modifiers>
+(10-20) to all Attributes
Adds (15-20) to (21-30) Chaos Damage
+(17-23)% to Chaos Resistance
<Two Random Herald of Agony modifiers>
Rare Gloves(Gloves) Rare Gloves - for extra defensive stats and Chaos Damage over Time Multiplier bonus. Again, aim to get a base with an Evasion Rating
Min. requirements:
50 Maximum Life
15% Chaos Damage over Time Multiplier
Evasion Rating
Optional affixes:
Elemental Resistances
Attack Speed
Damage while Leeching/Damage During any Flask effect
Asenath's Gentle Touch(Gloves) Asenath's Gentle Touch - Use it if you're able to apply more than one Curse via Whispers of Doom or a Rare Body Armour. It upgrades your clear speed and Blinds enemies for more survivability.
+(20-30) to Intelligence
+(60-80) to maximum Life
+(60-80) to maximum Mana
Curse Enemies with Temporal Chains on Hit, with 40% increased Effect
Non-Aura Curses you inflict are not removed from Dying Enemies
Enemies near corpses affected by your Curses are Blinded
Enemies Killed near corpses affected by your Curses explode, dealing
3% of their Life as Physical Damage
Abyss Jewel(Jewel) Abyssal Jewels - you are most likely going to use a Stygian Vise, so you will be able to use an extra Abyss Jewel. It's best to look for one with bonus Life and missing Attributes or Resistances
Min. requirements:
35 Maximum Life
Missing Attributes/Resistances
Optional affixes:
Damage if you've Killed Recently
Cobalt Jewel(Jewel) Rare Jewels - on regular Jewels you want extra Life and Chaos DoT Multiplier. You can also get some Resistances and Attributes here as well 
Min. requirements:
6% Maximum Life
+#% to Chaos Damage over Time Multiplier
Optional affixes:
Elemental Resistances
Large Cluster Jewel(Jewel) Large Cluster Jewel - you should use one Large Cluster Jewel with at Least the Touch of Cruelty Passive that significantly boosts your damage
Recommended affixes:
1 Added Passive Skill is Touch of Cruelty
1 Added Passive Skill is Unholy Grace
1 Added Passive Skill is Wicked Pall
Watcher's Eye(Jewel) Watcher's Eye - one of the best Jewels in the game, which is used by the majority of builds that use any Aura. You want Watcher's Eye with Malevolence modifiers - preferably Damage over Time Multiplier on it
(4-6)% increased maximum Energy Shield
(4-6)% increased maximum Life
(4-6)% increased maximum Mana
<Two or Three random aura modifiers>
Conqueror's Efficiency(Jewel) Replica Conqueror's Efficiency - reduces the base Mana cost of your Skills, decreasing the chance of running out of Mana
4% increased Skill Effect Duration
+5 to Maximum Rage
Non-Channelling Skills have -9 to Total Mana Cost
The Siege(Jewel) The Siege - you can use Kineticism to Maim and Knock back enemies on Hit, reducing their Movement Speed and pushing them back for your own safety
Adds Kineticism
Vorana's Preparation(Flask) Vorana's Preparation - generates Ward when used, and applies to Debilitate to enemies when the Effect ends, reducing the damage of nearby enemies
Restores Ward on use
(-10 to 10)% increased Charges used
Debilitate nearby Enemies for 2 Seconds when Flask Effect ends
Flask Effect is removed when Ward Breaks
Culling Strike during Flask Effect
Witchfire Brew(Flask) Witchfire Brew - grants increased Damage over Time and Despair Aura, which is an easy way to apply your main Curse in this setup
100% increased Evasion Rating
Creates a Smoke Cloud on Use
50% increased Charges used
(25-40)% increased Damage Over Time during Flask Effect
Grants Level 21 Despair Curse Aura during Flask Effect
Atziri's Promise(Flask) Atziri's Promise - use this flask for extra Chaos Resistance and life leech during its effect
+35% to Chaos Resistance
2% of Chaos Damage Leeched as Life during Flask effect
Gain (5-8)% of Physical Damage as Extra Chaos Damage during effect
Gain (5-8)% of Elemental Damage as Extra Chaos Damage during effect
Other suggested Flasks:
  1. Divine Life Flask with increased amount recovered and Bleed removal
  2. Enduring Mana Flask of the Monkey for increased Accuracy
  3. Quicksilver or Silver Flask of Heat for Freeze removal
  4. Jade Flask with a random Ailment Removal
  5. Quartz Flask with a random Ailment Removal
Vorana's PreparationWitchfire BrewDivine Life FlaskEnduring Mana FlaskQuicksilver Flask

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