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Fallout 76 Cutthroat 1H Melee build - Odealo

Fallout 76 Cutthroat 1H Melee build - Odealo

Powerful Melee build for true role players

1H Melee
Fallout 76 Build

General information

Our One-handed Melee Cutthroat build is a very interesting Melee build based on very fast one-handed bladed weapons. It also utilizes permanent Radiation, which grants:

  1. Health Regeneration (further enhanced by Healing Factor mutation)
  2. Increases your Strenght and Melee Damage via the Radicool Perk
  3. Increases your damage by inflicting Radiation on melee attacks (the faster the weapon, the more Radiation you apply)
  4. Find meat tissue when using Stimpacks
  5. Lower your Health, which increases the rate at which you trigger Nerd Rage and Serendipity

This build does not use a Power Armor and has been specifically made for playing solo. You can of course easily swap the Perks and use a Power Armor or play as a part of a team. Also, I find this build very fun to play in PvP. Getting hit back by other players is very common, and they find out real quick it wasn't a good idea :) 

Below you will find all the recommended Perks for each of the SPECIAL attributes and a brief introduction to this builds equipment and mutations.

You can also check our other builds on FO76 Builds and a beginner's guide to character customization

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SPECIAL Attributes and Perk Cards



Blocker Perk

Take 45% less damage from your opponents' melee attacks


Every point of Strength adds +4 Damage Resist (Max 80). (No Power Armor)


Your one-handed melee weapons now do +10% damage


Your melee weapons ignore 75% of your target's armor

Martial Artist

Your melee weapons weigh 60% less, and you can swing them 30% faster

Sturdy Frame

Armor weighs 50% less than normal

Strength is the most important attribute for any melee character. Strength directly increases your Melee Damage and maximum carry weight. If you manage to get Strength above 15 via mutations, other Perks etc. you can take a higher level of the Gladiator Perk (and possibly Expert Gladiator too)



Glow Sight

Deal +20% damage to glowing enemies

Perception is the least important SPECIAL attribute in this build. You can pick the Glow Sight Perk for some extra damage against glowing enemies or any other Perk you find useful



Adamantium Skeleton

Your limb damage is completely eliminated


Radiation now regenerates even more of your lost Health!

Good Doggy

Eating dog food is now three times as beneficial

Iron Clad

Gain 50 Damage and Energy Resistance while not wearing Power Armor


The greater your Rads, the greater your Strength (max +5 STR)!

Endurance is an essential attribute in this build. It increases your maximum Health and Health Regeneration. Also, if you decide to play your character as described in this build, with permanent radiation at approximately 25-40%, Endurance will significantly increase your Strength and melee damage



Lone Wanderer

When adventuring alone, take 10% less damage and gain 10% AP regen

Overly Generous

Rads increase your chance to inflict 50 Rads with melee attacks!


Reduce your target's damage output by 30% for 2 seconds after you attack

Charisma has several useful Perks even when playing solo. Overly Generous grants a chance to inflict Rads with melee attacks, and since you are using fast one-handed weapons, this will proc quite often. On the other hand, Suppressor is a very good defensive Perk, and also it perfectly fits this build in terms of PvP performance



Makeshift Warrior

Melee weapons break 20% slower and you can craft Tier 2 melee weapons

Nerd Rage

While below 20% Health, gain 40 Damage Resist, 20% damage and 15% AP regen

Nerd Rage is one of the best Perks you can take when you plan to have your Health lowered at all times by radiation. And Makeshift Warrior is a quite useful Perk, but you may as well take anything else in its place



Action Boy

Action Points regenerate 45% faster

Adrenaline 1

Gain +6% (max 36%) damage for 30s per kill. Duration refreshes with kills

Agility increases your maximum AP and AP Renegeration which is critical for any build. Action Boy is extremely helpful and makes your gameplay much smoother. On the other hand, Adrenaline is the best single-point spent on a single Perk in the game in terms of DPS bonus



Luck of the Draw

Chance your weapon will repair itself even more when hitting an enemy

Mystery Meat

Stimpaks may generate edible meat tissue. Higher Rads improve the chance


While below 30% health, gain a 45% chance to avoid damage

Bloody Mess

15% bonus damage means enemies may explode into a gory red paste.


You will never mutate from rads and Radaway will never cure mutations.

Luck is a very important attribute in Fallout 76. It can affect any action your character takes. Bloody Mess is one of the best DPS Perks, Serendipity is a true Lifesaver, and Starched Genes allows you to keep your beneficial mutations forever.

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ARMOR: In this build, you can use a wide variety of swords, knives, and other bladed weapons. Ripper is of notable mention, being one of the fastest weapons in the game. However, you will be most likely using Switchblades and Combat Knives that match your current level

WEAPON: Combat Armor is the best option for this build. Until you get a complete set you can use pretty much anything, but try to focus on Damage Resistance over Energy Resistance

CHEMS: Melee characters have a lot of interesting Chems take can take to improve their DPS and Damage Resistance. Psychobuff is the best Chem in the game for this build, which increases your Strenght, Endurance, Damage, and maximum Health. Bufftats are quite useful too for the bonus Strenght, Endurance, and max. Health, but the Perception bonus is negligible. Remember not to use Chems if you manage to get the Healing Factor mutation unless you are extremely eager to win a PvP fight


This build is heavily reliant on the mutations listed below. They aren't mandatory, but they are all insanely powerful. Remember to use the Starched Genes Perk when you get the mutations you want 

  1. Healing Factor - greatly increases your Health Regeneration, but reduces the effect of all Chems by 55%. One of the best mutations for this build
  2. Twisted Muscles - which increases your Melee Damage greatly and grants higher chance to cripple limbs. As the downside, it reduces your weapon accuracy
  3. Adrenal Reaction - another interesting mutation for this build. It increases your Damage and Health Regeneration when on low HP, but reduces maximum HP. This Perk is a double-edged sword, as you will be running on quite low HP yourself, but definitely, it's worth considering

On Odealo multiple sellers compete for your attention. You are guaranteed to find Fallout 76 Caps and Items at the best prices.

If you have any suggestions related to this build or you have a suggestion for our future build, let us know in the comments below.

Pictures used in this article are the intellectual property of Bethseda Softworks LLC.